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pc加拿大预算预测飞飞:于典科 教授

来源: 发布时间:2018-01-28 21:44:22


  于典科,pc加拿大预算预测飞飞特聘教授,博士生导师,博士后合作导师,pc加拿大预算预测飞飞常务副院长,卫生毒理学科负责人。入选中组部青年千人计划和泰山学者青年专家,主要学术兼职为中国毒理学会生化与分子毒理专业委员会主任委员、中国环境诱变剂学会生物标志物专业委员会秘书长和中华预防医学会卫生毒理学分会常务委员,任美国毒理学会官方期刊Toxicol   Sci编委。2005年于山东大学完成本科和硕士学业,获遗传学硕士学位,2008年于北京协和医学院获肿瘤学博士学位。2005年开始从事遗传因素调控肿瘤相关基因及发病风险的生物学机制研究,2013年起受邀赴美国国家毒理学研究中心(NCTR)进行非编码RNA调控毒物应答基因的机制研究。

  研究方向为系统毒理学,解析遗传和表遗传因素在环境毒物的代谢酶诱导、细胞损伤修复、促进复杂疾病发生发展中的调控机制,应用系统生物学手段建立基于毒性通路构建毒物毒作用模式(MOA)和有害结局路径(AOP)的方法,为新化学品的毒性评价和风险评估提供了新的策略。现主持自然科学基金重大研究计划培育项目和面上项目各1项,作为核心骨干参与国家自然科学基金重大研究计划集成项目和国家重大研究计划各1项。发表SCI论文百余篇,第一/通讯作者论文42篇,总引用5980次,H-指数43。

一、主要研究方向

1.系统毒理学

2.环境毒理学

3.化学性肝损伤的毒性机制

4.化学致癌机制

二、代表性科研成果

1.  Luo J#, Song G#, Chen N#, Xie M, Niu X, Zhou S, Ji Y, Zhu X, Ma W,  Zhang Q, Yu D*. Ferroptosis contributes to ethanol-induced hepatic cell  death via labile iron accumulation and GPx4 inactivation. Cell Death  Discov. 2023 Aug 25;9(1):311.

2.  Luo J#, Ji Y#, Chen N, Song G, Zhou S, Niu X, Yu D*. Nuclear miR-150  enhances hepatic lipid accumulation by targeting RNA transcripts  overlapping the PLIN2 promoter. iScience. 2023 Sep 6; 107837.

3.  Xu L#, Li Y#, Ma W, Sun X, Fan R, Jin Y, Chen N, Zhu X, Guo H, Zhao K,  Luo J, Li C, Zheng Y, Yu D*. Diesel exhaust particles exposure induces  liver dysfunction: Exploring predictive potential of human circulating  microRNAs signature relevant to liver injury risk. J Hazard Mater. 2023  Sep 15; 458: 132060.

4.  Fan R#, Xu L#, Cui B, Li D, Sun X, Qi Y, Rao J, Wang K, Wang C, Zhao K,  Zhao Y, Dai J, Chen W, Shen H, Liu Y, Yu D*. Genomic Characterization  Revealed PM2.5-Associated Mutational Signatures in Lung Cancer Including  Activation of APOBEC3B. Environ Sci Technol. 2023 May  2;57(17):6854-6864.

5.  Li C#, Jiang L#, Zhang D, Qi Y, Wang X, Jin Y, Liu X, Lin Y, Luo J, Xu  L, Zhao K, Yu D*. Human health risk assessment of 6:2 Cl-PFESA through  quantitative in vitro to in vivo extrapolation by integrating cell-based  assays, an epigenetic key event, and physiologically based  pharmacokinetic modeling. Environ Int. 2023 Mar; 173: 107846.

6.  Ma W#, Xu L#, Sun X, Qi Y, Chen S, Li D, Jin Y, Chen N, Zhu X, Luo J,  Li C, Zhao K, Zheng Y, Yu D*. Using a human bronchial epithelial  cell-based malignant transformation model to explore the function of  hsa-miR-200 family in the progress of PM2.5-induced lung cancer  development. Environ Pollut. 2023 Feb 15; 319: 120981.

7.  Li C#, Jiang L#, Qi Y, Zhang D, Liu X, Han W, Ma W, Xu L, Jin Y, Luo J,  Zhao K, Yu D*. Integration of metabolomics and proteomics reveals the  underlying hepatotoxic mechanism of perfluorooctane sulfonate (PFOS) and  6:2 chlorinated polyfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA) in  primary human hepatocytes. Ecotoxicol Environ Saf. 2023 Jan 1;  249:114361.

8.  Jin Y#, Zhang Q#, Liu Y, Guan H, Shou Y, Du C, Luo J, Zhao K, Li C, Xu  L, Ma W, Chen N, Zheng Y, Yu D*. Identifying microRNAs that drive  BaP-induced pulmonary effects: Multiple patterns of mechanisms  underlying activation of the toxicity pathways. Environ Int. 2022  Dec;170: 107588.

9.  Jin Y, Qi G, Feng M, Yu D*. The path via pathway-based approaches  towards safety assessment: A concise review. Toxicol Appl Pharmacol.  2022 Oct 1;452: 116195.

10.  Chen N#, Luo J#, Hou Y#, Ji Y, Xie M, Song G, Yu D*. miR-29c-3p  promotes alcohol dehydrogenase gene cluster expression by activating an  ADH6 enhancer. Biochem Pharmacol. 2022 Sep; 203: 115182.

11.  Xu L#, Ma W#, Jin Y, Sun X, Chen N, Zhu X, Luo J, Li C, Zhao K, Zheng  Y, Yu D*. N, N-dimethylformamide exposure induced liver abnormal  mitophagy by targeting miR-92a-1-5p-BNIP3L pathway in vivo and vitro.  Sci Total Environ. 2022 Sep 15; 839:156218.

12.  Xu L, Chen W, Chen J, Jin Y, Ma W, Qi G, Sun X, Luo J, Li C, Zhao K,  Zheng Y, Yu D*. PIWI-interacting RNA-23210 protects against  acetaminophen-induced liver injury by targeting HNF1A and HNF4A. Biochem  Pharmacol. 2022 Mar; 197:114897.

13.  Jin Y#, Qi G#, Shou Y, Li D, Liu Y, Guan H, Zhang Q, Chen S, Luo J, Xu  L, Li C, Ma W, Chen N, Zheng Y, Yu D*. High throughput data-based,  toxicity pathway-oriented development of a quantitative adverse outcome  pathway network linking AHR activation to lung damages. J Hazard Mater.  2022 Mar 5; 425:128041.

14.  Li C, Jiang L, Jin Y, Zhang D, Chen J, Qi Y, Fan R, Luo J, Xu L, Ma W,  Zhao K, Yu D*. Lipid metabolism disorders effects of 6:2 chlorinated  polyfluorinated ether sulfonate through Hsa-miRNA-532-3p/Acyl-CoA  oxidase 1(ACOX1) pathway. Ecotoxicol Environ Saf. 2021 Nov 24;  228:113011.

15.  Luo J#, Xie M#, Hou Y, Ma W, Jin Y, Chen J, Li C, Zhao K, Chen N, Xu L,  Ji Y, Zhang Q, Zheng Y, Yu D*. A novel epigenetic mechanism unravels  hsa-miR-148a-3p-mediated CYP2B6 downregulation in alcoholic hepatitis  disease. Biochem Pharmacol. 2021 Jun; 188:114582.

16.  Xu L, Zhao Q, Li D, Luo J, Ma W, Jin Y, Li C, Chen J, Zhao K, Zheng Y,  Yu D*. MicroRNA-760 resists ambient PM2.5-induced apoptosis in human  bronchial epithelial cells through elevating heme-oxygenase 1  expression. Environ Pollut. 2021 Sep 1; 284:117213.

17.  Luo J#, Hou Y#, Ma W, Xie M, Jin Y, Xu L, Li C, Wang Y, Chen J, Chen W,  Zheng Y, Yu D*. A novel mechanism underlying alcohol dehydrogenase  expression: hsa-miR-148a-3p promotes ADH4 expression via an  AGO1-dependent manner in control and ethanol-exposed hepatic cells.  Biochem Pharmacol. 2021 Jul; 189:114458.

18.  Jin Y#, Feng M#, Ma W#, Wei Y, Qi G, Luo J, Xu L, Li X, Li C, Wang Y,  Li D, Chen J, Zhao Y, Hou Y, Zhao Q, Jiang L, Xie M, Zheng Y, Yu D*. A  toxicity pathway-oriented approach to develop adverse outcome pathway:  AHR activation as a case study. Environ Pollut. 2021 Jan 1;268(Pt  B):115733.

19.  Xu L#, Zhao Q#, Luo J, Ma W, Jin Y, Li C, Hou Y, Feng M, Wang Y, Chen  J, Zhao J, Zheng Y*, Yu D*. Integration of proteomics, lipidomics, and  metabolomics reveals novel metabolic mechanisms underlying N,  N-dimethylformamide induced hepatotoxicity. Ecotoxicol Environ Saf. 2020  Dec 1; 205:111166.

20.  Wang X#, Zhao Y#, Luo J, Xu L, Li X, Jin Y, Li C, Feng M, Wang Y, Chen  J, Hou Y, Zhao Q, Zhao J, Ning B, Zheng Y, Yu D*. MicroRNA  hsa-miR-1301-3p Regulates Human ADH6, ALDH5A1 and ALDH8A1 in the  Ethanol-Acetaldehyde-Acetate Metabolic Pathway. Mol Pharmacol. 2020  Aug;98(2):120-129.

21.  Yu D#, Wu L#, Gill P, Tolleson WH, Chen S, Sun J, Knox B, Jin Y, Xiao  W, Hong H, Wang Y, Ren Z, Guo L, Mei N, Guo Y, Yang X, Shi L, Chen Y,  Zeng L, Dreval K, Tryndyak V, Pogribny I, Fang H, Shi T, McCullough S,  Bhattacharyya S, Schnackenberg L, Mattes W, Beger RD, James L*, Tong W*,  Ning B*. Multiple microRNAs function as self-protective modules in  acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018  Feb;92(2):845-858.

22.  Yang X#, Yu D#, Ren Y, Wei J, Pan W, Zhou C, Zhou L, Liu Y, Yang M*.  Integrative Functional Genomics Implicates EPB41 Dysregulation in  Hepatocellular Carcinoma Risk. Am J Hum Genet. 2016 Aug 4;99(2):275-86.

23.  Wei Q#*, Yu D#, Liu M#, Wang M#, Zhao M, Liu M, Jia W, Ma H, Fang J, Xu  W, Chen K, Xu Z, Wang J, Tian L, Yuan H, Chang J, Hu Z, Wei L, Huang Y,  Han Y, Liu J, Han D, Shen H, Yang S, Zheng H, Ji Q, Li D, Tan W, Wu C*,  Lin D. Genome-wide association study identifies three susceptibility  loci for laryngeal squamous cell carcinoma in the Chinese population.  Nat Genet. 2014 Oct;46(10):1110-4.

三、代表性科研及人才项目

1. 国家自然科学基金委,面上项目,81973075,piRNA调控脂类代谢及影响多环芳烃致肺癌的作用机制研究,2020/01-2023/12,55万,在研,主持

2. 国家自然科学基金委,重大研究计划集成项目,91943301,大气细颗粒物健康:Φ南低扯纠硌в胂低沉餍胁⊙а芯,2020/01-2022/12,1200万,已结题,研究负责人(100万)

3. 国家自然科学基金委,重大研究计划培育项目,91743113,miRNA、lncRNA及其交互作用在PM2.5致肺癌中的机制研究,2018/01-2020/12,75万,已结题,主持

4. 科技部,国家重点研发计划课题,SQ2017YFC1600801,食品典型污染物低剂量暴露的毒作用模式研究,2018/01-2021/12,409万,已结题,核心骨干(49万)

5. 中共中央组织部,国家海外高层次人才计划(QNQR),2019.01-2021.12

6. 山东省组织部,泰山学者青年专家人才计划,2019.01-2023.12

四、主要科学技术奖励

1.FDA Group Recognition Award,2015.

2.教育部自然科学一等奖, 2012年10月,第五位

3. 北京市科学技术二等奖, 2012年11月,第六位


联系方式:

E-mail:dianke.yu@qdu.edu.cn



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