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pc加拿大预算预测飞飞:赵坤明 助理教授

来源: 发布时间:2020-07-29 09:40:44

  


  赵坤明,1992年生。2020年6月毕业于哈尔滨工业大学,获得生物医学工程博士学位。2020年入职pc加拿大预算预测飞飞,助理教授,青年卓越人才,硕士生导师。

一、主要研究方向

化学致癌进程的分子机制研究(功能性蛋白质及表观遗传调控方向)

二、代表性研究成果

1. Kunming Zhao#, Xingwen Wang#, Dong Zhao#, Qingyu Lin, Yi Zhang, Ying Hu*. lncRNA HITT Inhibits Lactate Production by Repressing PKM2 Oligomerization to Reduce Tumor Growth and Macrophage Polarization. Research (Wash D C), 2022: 9854904. (IF=11)

2. Kunming Zhao, Xingwen Wang, Ying Hu*. Identification of lncRNA-Protein Interactions by CLIP and RNA Pull-Down Assays. Long Non-Coding RNAs in Cancer, Humana Press, 2021.

3. Kunming Zhao, Ying Hu*. Microbiome harbored within tumors: a new chance to revisit our understanding of cancer pathogenesis and treatment. Signal Transduction and Targeted Therapy, 2020, 5(1): 136-138. (IF=39.3)

4. Kunming Zhao, Xingwen Wang, Xuting Xue, Li Li, Ying Hu*. A long non-coding RNA sensitizes genotoxic treatment by attenuating ATM activation and homologous recombination repair in cancers. Plos Biology, 2020, 18(3): e3000666. (IF=9.8)

5. Kunming Zhao, Miao Yu, Yifu Zhu, Dong Liu, Qiong Wu, Ying Hu*. EGR-1/ASPP1 inter-regulatory loop promotes apoptosis by inhibiting cyto-protective autophagy. Cell death & disease, 2017, 8(6): e2869. (IF=9.0)

6. Wenjie Ge#, Kunming Zhao#, Xingwen Wang, Huayi Li, Miao Yu, Mengmeng He, Xuting Xue, Yifu Zhu, Cheng Zhang, Yiwei Cheng, Shijian Jiang, Ying Hu*. iASPP is an antioxidative factor and drives cancer growth and drug resistance by competing with Nrf2 for Keap1 binding. Cancer Cell, 2017, 32(5): 561-573. (Featured article, IF=50.3)

7. Xingwen Wang, Li Li, Kunming Zhao, Qingyu Lin, Xuting Xue, Wenjie Ge, Hongjuan He, Dong Liu, Qiong Wu, Ying Hu*. A novel LncRNA HITT forms a regulatory loop with HIF-1α to modulate angiogenesis and tumor growth. Cell Death & Differentiation, 2020, 27(4):1431-1446. (IF=12.4)

8. Huayi Li#, Wenxin Zhang#, Kunming Zhao, Dong Zhao, Shanliang Zheng, Ying Hu*. A previously identified apoptosis inhibitor iASPP confers resistance to chemotherapeutic drugs by suppressing senescence in cancer cells. Journal of Biological Chemistry, 2020, 295(12):4049-4063. (IF=4.8)

三、主要科研项目

1. 国家自然科学基金委员会,青年项目,82204087,tRNA衍生片段tRF-Gly-GCC调控支链氨基酸关键代谢酶在亚硝胺诱发肝癌中的作用机制研究,2023-01至2025-12,30万元,在研,主持;

2. 山东省自然科学基金,青年项目,ZR2021QH278,LncRNA ZNF674-AS1调控神经母细胞瘤发生发展的机制研究,2022-01至2024-12,15万元,在研,主持。


联系方式

E-mail:zkm6711217@163.com(常用邮箱)或zhaokunming@qdu.edu.cn


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